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| Company News | Interventional & Surgical Innovations, LLC (ISI) Announces the Signing of a New Technology Agreement with Dr. Juan Parodi. New York, NY - September 17th 2007 – Interventional & Surgical Innovations, LLC, and Dr. Juan Parodi have signed an agreement to develop and commercialize a unique and proprietary guidewire platform technology for greatly simplifying minimally invasive interventional surgical procedures. Guidewires are used in the vasculature to guide all types of medical treatments, such as angioplasty and stent delivery. ISI will provide both funding as well as development and regulatory expertise to bring this new product to the U.S. market in the 2008/2009 timeframe. Dr. Juan Parodi is a prominent vascular surgeon and inventor, currently practicing at the University of Miami as a Professor of Vascular and Endovascular Surgery. Mr. Hinchliffe commented, “We are thrilled that Dr. Parodi has brought this unique platform technology to ISI and are excited to have the opportunity to continue developing and commercialize this revolutionary new technology. Dr. Parodi, once again, has come up with a truly innovative device with significant market potential. This new guidewire platform will save surgeon and OR time and simplify complex procedures by reducing guidewire exchanges and providing significant handling advantages over anything available today.” About Interventional & Surgical Innovations LLC ISI is a medical device development platform focused on analyzing, IP protecting, prototyping, and funding innovations that address unmet clinical needs and is based in New York. For more information about ISI, please visit our web site at www.isidevices.com. About Trevi Health Ventures Trevi Health Ventures is a healthcare private equity firm managed by a team of experienced investment and operating professionals. The firm has strategic sponsors and advisors comprised of leading healthcare thought leaders, professionals and executives. The firm invests in development and growth-stage companies in medical devices, biopharmaceuticals and healthcare services. The firm was founded in 2005 and has offices in New York City and London. SOURCE: Interventional & Surgical Innovations, LLC Company Contact Peter Hinchliffe, CEO of Interventional & Surgical Innovations, LLC
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